All chapters have been extensively updated by experts in the field. In addition, this edition includes 25 new chapters and more than 100 new authors. The pathophysiologic approach to evaluating patients on the basis of their presentation continues to receive emphasis in an enriched section on the cardinal manifestations of disease. A new section focuses on aging, its demographics and biology, and distinctive clinical issues affecting older patients. The e-chapters have increased in number from 39 to 55 and include a new video atlas of neuro-ophthalmology, an audio-enhanced chapter on the approach to a patient with a heart murmur, a case-based teaching exercise in fluid and electrolyte imbalances and acid-base disturbances, and explorations of infectious complications of burns and bites. New videos demonstrate the neurologic examination and several commonly performed medical procedures. A new chapter focuses on neuropsychiatric problems among war veterans. E-chapters on altitude sickness and hyperbaric and diving medicine form a new section on medical effects of changes in environmental pressure. and You can use search engine to find subjects you want.