Yu-Gi-Oh R takes place following Yugi Mutou's victory in the Battle City tournament. Yako Tenma, the protégé' and adopted son of Maximillion Pegasus, decides to avenge his teacher's defeat at the hands of Yugi, believing him to be responsible for Pegasus' alleged death. After taking over KaibaCorp while Seto Kaiba is in the United States, Tenma kidnaps Anzu Mazaki, prompting Yugi and his friend Katsuya Jonouchi to face Tenma's RA Project and the duel professors. Seto Kaiba and his brother Mokuba also come to the scene to rescue the company.
Many of the characters that are exclusive to Yu-Gi-Oh! R have names that are also Intel codenames. Intel codenames in turn are frequently taken from names of cities and towns near Intel factories in Oregon, Washington, and other locations.
Yako Tenma (天馬 夜行 Tenma Yakō?) - The kōhai (protégé) and adopted son (often mistaken, or mistranslated as younger brother) of Pegasus J. Crawford (Maximillion Pegasus in the English version) who wants revenge for Pegasus' defeat.
Deschutes Lew (デシェーツ・ルー Deshētsu Rū?) - The first professor. Yugi defeats him. He is named after the Deschutes River and Deschutes County, Oregon. "Deschutes" is also a pre-release codename for the 333 MHz P6 Intel Pentium II chip.
Tilla Mook (ティラ・ムーク Tira Mūku?) - The second professor, who plays a vampire-themed deck. Yugi defeats her. She is named after Tillamook, Oregon. "Tillamook" is also a pre-release codename for the Embedded 266 MHz Intel Pentium MMX chip.
Klamath Osler (クラマス・オースラー Kuramasu Ōsurā?) - The third professor, who has such bad luck. Jonouchi defeats him. He is named after Klamath Falls, Oregon. "Klamath" is also a pre-release codename for the 300 MHz Intel Pentium II chip.
Kirk Dixon (カーク・ディクソン Kāku Dikuson?) - The fourth professor, who plays a machine-themed deck. Yugi defeats him. "Dixon" is also a pre-release codename for the 333 MHz 1.6V Intel Pentium II chip. His key card Commander Covington (督戦官コヴィントン Tokusenkan Covinton) originates from "Covington" codenamed for the 266 MHz P6 Intel Pentium II chip.
Pete Coppermine (ピート・コパーマイン Pīto Kopāmain?) - The fifth professor, who plays a mutant-themed deck. Jonouchi defeats him. He is named after the Coppermine River in Oregon. The name of that river was used as a codename for the 866 MHz Flip Chip Pin Grid Array (FCPGA) Pentium III (P3-850) microprocessor, which was released by Intel.