Any nuclear explosion would have wide-ranging long-term catastrophic effects that could threaten the survival of humankind. Radioactive contamination would cause genetic mutations and cancer across many generations.
The dominant effects of a nuclear weapon are the same physical damage mechanisms as conventional explosives but the energy produced millions of times more per gram and the temperatures reached are in the tens of megakelvins. Nuclear weapons are quite different from conventional weapons because of the huge amount of explosive energy they can put out and the different kinds of effects they make like high temperatures and radiation.
The devastating impact of the explosion does not stop after the initial blast as with conventional explosives. A cloud of radiation travels from the epicenter of the explosion causing an impact to life forms even after the heat waves have ceased.
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